A love letter to a beautiful drug....

User's GuideMDMA Science
Ask TheDEA: How much MDMA should people take for therapy?

The ‘easy’ (but not entirely accurate) answer is that the current research being run by MAPS uses 120 mg.

But let’s go down the rabbit hole and see why they chose that amount! 🙂

The first problem in deciding dosages is that not everybody will be affected the same way.

On average, larger people are less sensitive to MDMA; your weight matters. You might think of it as being a bit like peeing in the pool; the bigger the pool is, the less concentrated the pee will be. A bigger body gives more volume for the drug to spread out in.

Your body composition also matters; if you’re mostly muscle, you’ll be less effected than if you’re very overweight. That’s because MDMA dissolves easily in water, but not very easily in fat. Blood and muscle are mostly water, but fat doesn’t have nearly as much water in it (so more of the MDMA stays in the ‘wet’ tissues of your body, like your blood and brain.)

Sex matters as well. On average, men experience stronger ‘stimulant’ effects from MDMA (energy, increased activity levels, blood pressure and pulse.) Women, on the other hand, tend to experience stronger ‘psychedelic’ effects at the same dose, with larger shifts in mood and perspective.

But that’s not always true. Personal genetics matter as well. Some people’s brains are more sensitive to serotonin, for instance, or more or less able to release it. Some people are also better at breaking down MDMA (mostly in the liver), which can reduce the strength of the experience by actually reducing the amount of MDMA in their system.

And then there’s mental/physical state and tolerance. An exhausted person isn’t going to get as much out of the same dose of MDMA as they would when well rested and excited. After all, drugs amplify or modify what’s already going on in your head. It’s not drug = experience. It’s you + drug = experience!

So, even the most reasonable and informed ‘standard dose’ may be significantly off the mark for any given individual. An exceptionally small/sensitive person might be uncomfortable at 80 mg, while a huge professional athlete might be comfortable at as much as 300 mg!

And then there’s the question of ‘how high did you want to be?’

For some people, the goal is just to feel a bit more relaxed and social. In that case, low doses (around 70 mg for a 70 kg/155 lb person) would likely give them what they want.

On the other hand, if you think the only proper MDMA experience means a spiritual, overwhelming, at-one-with-the-universe explosion of sensory overload joy in your brain, then a dose closer to 140 mg for that 70 kg (155 lb) person is more likely to be the ‘right’ dose.

In the case of MDMA being used for PTSD therapy, the goal is to produce an intense experience. So, a larger dose is usually going to be appropriate.

As far as why 120 mg was chosen for the research, it comes down to a bit of science, a bit of bureaucracy, and a bit of marketing. The goal of the research is to get FDA approval so MDMA can be legally used by therapists. That requires picking a dosage that you’re actually going to sell the pills in, so the FDA can decide if THAT dosage is safe and effective. 120 mg was chosen because it was likely to be safe for the more sensitive patients, while being a high enough dose to give enough people strong experiences (strong enough to help them) to show that the medication is effective.

So, while it would make more sense to tailor the dosage to each patient based on their particular profile, that would throw the system into chaos. Want a drug approved for medical use? Then you need to pick a dosage to sell and show the FDA that it’s reasonably safe and effective.

120 mg isn’t a special ‘ideal’ or ‘right’ dose. It’s a reasonable dose for most people for what the researchers are trying to do. Your milage may vary; perhaps by a lot!

But that doesn’t really answer the main question, does it? How much MDMA to take, for therapy or fun? Let’s move past the theory and throw down some reasonable estimates:

For a small (50 kg, 110 lb) person, 50 mg is likely to have mild but clearly felt effects. 75 mg will likely produce a somewhat strong (but usually not overwhelming) experience. 100 mg might produce a quite intense experience.

For a more ‘medium’ sized person (70 kg, 155 lbs) 70 mg will likely give a mild experience, while 105 mg will likely give a moderately strong experience, and 140 mg is likely to give an intense experience.

For a large person (100 kg, 220 lbs), 100 mg might only by a mild experience, while 150 mg will probably give a moderately strong experience, and 200 mg is likely to be pretty intense.

If you’re new to MDMA, it’s best to start with a lower dose until you know how you respond to it.

Measuring out drugs in such small dosages can be a real challenge. Small, inexpensive, milligram scales (often sold for jewelry/gemstones) are easy to find. Another option is if you have a gram of MDMA powder, you can dilute it into water and then measure the water to dose. For instance, dissolving that 1 gram of MDMA into 1 liter of water will give you a dose of 1 mg per ml. So, if you wanted to take 120 mg, you could then measure out 120 milliliters of the water and drink that. (Sorry about the taste. Yes, it’s nasty.)

As always, keep in mind that your brain needs time to recover! For most people, use should be limited to once a month or less. (But again, people vary. Some people seem OK with once a week use, while for others even once a month adds up and causes problems with mood, concentration, etc.)

MDMA declared a "Breakthrough Treatment" by FDA for PTSD

Exciting news from MAPS; the US Food and Drug Administration (responsible for approving new medications) has ruled that MDMA (molly, ecstasy) is a potential ‘Breakthrough Treatment‘; a drug so important in it’s potential to help people that it deserves special support.  That isn’t just a nice compliment; it means that the FDA will give the MDMA therapy trials special fast-track access to the drug approval process.

So far, MDMA therapy has been 68% successful in curing people suffering from severe PTSD that has resisted treatment by any other means.   The potential for this work to change (and save) many lives is extraordinary; people with PTSD often suffer such severe anxiety and depression that they withdraw from their lives and even commit suicide.   Unfortunately, the research is expensive.  MAPS has raised half of the estimated $25 million they’ll need to finish the last stage of research before the drug is made legal for medical use, but there’s still a long way to go!   If you would like to help, consider making a donation.

CAUTION: Lung damage from snorting MDMA

There’s been a recent medical report of a young man who died from snorting what seems to have been a very large amount of MDMA powder.   While the exact mechanism of death isn’t clear to me, there was clear evidence of severe damage to his lungs from the MDMA powder, which seems to be the result of vasoconstriction (greatly reduced local blood flow caused by MDMA tightening blood vessels) combined with the irritating/acidic properties of MDMA powder (‘molly’).

Snorting drugs has a long history of causing damage to the delicate tissues of the sinuses, but this is the first case I’ve seen where serious damage was caused directly to the lungs by snorting MDMA.  Although the risk is probably low (the young man in question seems to have taken a spectacularly high dose), it’s something for users to think about.

The safest way to take MDMA (and most other drugs) is orally, by swallowing the drug.  The digestive system is fairly tough, having evolved to handle all sorts of nasty things (like poisons, spoiled food, bacteria, etc.)


Ask The DEA: Can you mix MDMA (molly, ecstasy) in water or other beverages?

Certainly (it dissolves easily), although alkaloids (MDMA and many other drugs) are often very bitter-tasting.   If you don’t mind the flavor, MDMA itself is a fairly stable molecule; it should last a long time in liquid form (probably until the beverage ‘went bad’ and mold or other microorganisms ate the MDMA.)  Taking MDMA this way might cause it to take effect a little faster than usual (since it’s already dissolved), but otherwise the effects will be the same as taking a pressed pill or capsule.

Having a bottle of water (or juice or who knows what) spiked with MDMA does create a danger of accidental poisoning.   Somebody (such as a small child) might drink it without realizing that the odd flavor is a sign that something isn’t right.  So if you do want to drink your molly, be careful not to leave the spiked beverage sitting around where others might find it!

Is MDMA (Molly, ecstasy) illegal? Can I get MDMA from my doctor?

Yes, MDMA is generally illegal to make, have, or sell.  As usual, the United States was the driving force behind the global ‘drug war‘ against MDMA, convincing the UN to add it to an agreement that most member UN nations follow (to varying degrees.)  As a result, MDMA is more or less illegal in most (possibly all) countries.

There are exceptions for research and for prescription use, but MDMA hasn’t been approved yet as a prescription medication.  So, you can’t get it from your doctor yet (but you might be able to in 5-10 years.)  If you feel you might benefit from MDMA therapy, there’s a chance you might qualify to take part in one of the MAPS research projects.

Can drug dogs smell acid (LSD)?

It’s an old and common belief that LSD is “odorless and tasteless”.  Neither is quite true.  The reason people think it doesn’t have a smell or taste is simply because a tab of acid contains such tiny amounts of LSD that there isn’t enough for a person to smell or easily taste it. (For example, a gram of MDMA contains perhaps eight doses.  But a gram of LSD contains around 10,000 doses!)  But, if you get a large enough amount of it together even a human should be able to detect a smell to the drug.

So, it does have a smell.  How much LSD would you need to have on you in order for it to smell strongly enough for a dog to detect?  I can’t find an answer to that, I’m afraid, although it seems likely that in the usual scenario (a user with a couple tabs in a plastic bag) there seems to be no real chance of enough LSD getting into the air for a dog to pick up the scent.  (But most people carrying LSD will also smoke pot, which gives the dogs something much easer to smell on you and your clothes and alert on, even if you don’t have marijuana in your pockets.)

The more interesting question might be “are dogs trained to look for the smell of LSD?”  Sometimes, yes (they even make a ‘fake LSD’ scented substance for training dogs.)  So, there are certainly some drug dogs out there that have been trained to spot a shipment of LSD.  However, dogs are not trained to spot ‘drugs’ as a category.  Instead, they are trained to identify specific drugs. For instance, a dog might be trained to ‘alert’ when it smells marijuana or cocaine.  (Usually an ‘alert’ involves scratching at whatever the scent is coming from, but it varies.  Some dogs are trained to sit down next to the item and wait.)

Most dogs will be trained to spot several different drugs, but it’s rare for a dog to be trained to spot a large variety of drugs.  Most dogs simply can’t reliably be trained to do it, and each drug that the dog has been trained on requires consistent re-enforcement (you have to keep training the dog to look for that smell, as well as making sure it’s going after the right smell and not something else, like the smell of a plastic bag.)

As a result, most dogs will only alert on a couple of different drugs.  (If they’re trained on drugs at all; search dogs at airports, for instance, are often looking for food/animal products or explosives and wouldn’t react if they came upon a kilo of heroin.)  And, while LSD is certainly illegal and law enforcement has an interest in stopping it, it’s also one of the less common drugs and a low priority.  Most drug sniffing dogs will not be trained to identify it; it isn’t worth the trouble.

The drug sniffing dog is one of the most notoriously abused police tactics:  A dog handler can easily get the dog to ‘alert’ on command, giving them an excuse to search people they merely suspect or dislike.  Always say that you refuse to allow you or your property to be searched (but never physically resist); if the police officer has a legal right to search you they won’t ask.  For more information on what your rights are, check out Flex Your Rights.

Can you die from real MDMA?

Fake pills and fake ‘molly’ (MDMA powder) have been a big problem, but it is possible for even genuine, pure MDMA to cause death, even without the user making a mistake like drinking extreme amounts of water or mixing drugs.   Although MDMA overdose deaths are quite rare, they can be spectacularly ugly.  MDMA can reduce blood flow to your skin, which makes it harder to lose heat to your surroundings.  It can also greatly increase metabolism, causing your body to produce a lot more heat.  And since you’re high, you may not notice that something is wrong.  As a fatal overdose progresses, you tend to severely overheat.  This overheating starts to cause the breakdown of a lot of tissues, including the clotting mechanisms that stop bleeding.   You begin to bleed internally, while at the same time your muscles begin to break down, dumping a lot of toxic junk into your bloodstream.  All this ‘pollution’ overwhelms your already heat-weakened kidneys and liver, poisoning them.   You would typically suffer, fall into a coma, and die of multiple organ failure.

It might be tempting to think that overdosing on a drug as enjoyable as MDMA might be a nice way to go, but it’s one of the nastier deaths recreational drug use has to offer.   If you believe somebody has overdosed on any drug, get them prompt medical attention!  Call emergency services (like 911 in the US) without worrying about the consequences.  Angry parents and medical bills are never as big a problem as being dead.

So, yes; real MDMA can kill you.   The safest thing to do is not use drugs, but the next best thing is to use in moderation.   Try to stick to a single, moderate dose of MDMA; resist the urge to keep re-dosing to stay high all night long at a party, and try to know what you’re taking in terms of the strength of pills or dosage of powders.

Can I give my dog molly (MDMA)?

Uhhh. Probably, but…

The first question is “can a dog get high on MDMA the way a human can?” The experience might not be quite the same for a dog, but the areas of the brain (and the chemistry that controls them) involved in how drugs work are evolutionarily ‘highly conserved’. Which is to say, the wiring tends to work pretty much the same in dogs, rats, humans, etc. There’s also been a lot of research on MDMA’s effects on other animals that suggests they feel something similar to what we feel at recreational doses. So far so good; from a strictly neurological standpoint a dog can probably ‘roll’ (get high) on MDMA.

The first problem is dosage. Different animals can be more or less sensitive to a drug, and that’s before taking into account questions of the size of the dog, any health issues they might have, etc. A wrong assumption could result in a fatal overdose for your dog. MDMA overdoses can be a spectacular death; your body temperature runs out of control, you start to bleed internally, and your organs break down one after another. It’s a horrible way to go for any creature, human or otherwise.

Assuming you could figure out what the right dosage is, your dog might not handle getting high very well. There’s a famous case from the CIA’s MK-ULTRA project (where random people were poisoned with LSD, among many other strange and terrible things.) One of their victims had a very, very bad trip and eventually ended up committing suicide. It’s not safe to assume a dog won’t panic on the come-up and have a horrible experience.

Your dog also can’t explain it to you if something is wrong; if they had a bad reaction to the drug, you might not realize anything was wrong until it was too late to help them.

So, please don’t experiment on your pets. If you’re lucky, they might have fun. If not, they may be severely traumatized or even killed.

Have a question, crazy or otherwise?  Feel free to contact me.  Or, swing by the Bluelight forums and join the discussion!

Is molly different these days because of a new way of making it?

Probably not.  In recent years MDMA synthesis has shifted from using safrole and other traditional precursors as their starting material.  A chemical called PMK glycidate became popular as the starting material since it wasn’t regulated by law enforcement.  This has led some people to speculate that MDMA made with this new method might have a different balance of isomers.  Isomers are slightly different forms of the MDMA molecule, much the way a right and left shoe are almost identical, but mirror images of each other.  One isomer called S(+) is a powerful dopamine releaser and could be thought of as the euphoric ‘fire’ of MDMA.  The other isomer, R(-), is mostly a serotonin releaser and could be thought of as the warmth and empathy of the MDMA high.  MDMA sold on the streets is “racemic”; an equal mix of both isomers.  Chemists end up with a mix of the two isomers because the synthesis process isn’t selective; whether a given molecule will be created as one isomer or the other is random.

The traditional precursor (PMK, also called MDP2P) doesn’t come in isomers; there’s only one form, which gets randomized to either S(+) MDMA or R(-) MDMA during the synthesis process.   PMK glycidate (the starting material for the currently most popular method) has a bias; each molecule starts out as one isomer or another.   This has led some people to wonder if this couldn’t result in batches of MDMA that were (for instance) all or mostly just one isomer or the other.

However, the process for turning PMK glycidate into MDMA starts by breaking down the glycidate, turning it back into plain PMK (MDP2P), which eliminates any bias towards one isomer or the other (by eliminating what chemists call the chiral center.)

As a result, the end product is still randomly formed, giving a 50:50 mix of both MDMA isomers.

Which seems like it would solve the debate, but there is one potential catch:  The new method might in some cases introduce new contaminants that could, in theory, affect the high.  But, that shouldn’t be even a theoretical issue if the drug is properly purified during production.

Most cases of ‘weak molly’ are probably due to drugs that have been cut with other powders to make more money, or they could be entirely different drugs (such as the various ‘research chemicals’, drugs that the government hasn’t gotten around to outlawing yet.)  If you have a suspicious pill, there are excellent home testing kits, and you can even send it in to a lab for professional analysis through EcstasyData.org

Lab testing of ‘molly’, ‘ecstasy’, and MDMA powders and pills generally suggests that the MDMA supply these days is more trustworthy, purer, and stronger than ever before, but of course caution is always a good idea.

Have a question?  You can e-mail me, or join the discussion at Bluelight.

Welcome to TheDEA.org: The definitive guide to the drug MDMA (Molly, ecstasy) since 2003.

The User's Guide

The legendary guide to fun and safety!

Science and Statistics

How dangerous is MDMA (Molly, ecstasy)? Can it really make holes in your brain?
Soldier in helicopter


The origins and results of the ‘War on Drugs’
US Drug Enforcement Agency 1% effective (1/2/06)

Over at the other DEA, they hoisted champagne this New Year’s in celebration of their most successful year yet of hunting down drug-trade profits. According to Administrator Karen Tandy in remarks on C-SPAN, “up to” $1.9 billion in drugs, cash, cars, etc. were seized over the past year, representing about 3% of the total annual wealth produced by the US drug trade. (The most recent White House estimate I can find puts the total trade at about $65 billion a year.) When only drug seizures were counted, the total haul for the year was $477 million; well below 1% of the entire drug market. Tandy hailed this record level of seizures as proof that the drug war was working.

Roaring success is all a matter of perspective, it seems. 1% effective. You just can’t make these things up. If the Emperor has any clothes on, it’s no more than a G-string.

(Though perhaps the bigger lesson is ‘if you have a question, make an effort to properly research the answer.’ I had a question (how effective is the DEA?) I found the answer. And now it’s a part of the DEA Wikipedia page. And it’s never going away. Mwahahahah….)

The Mystery of 'Meth Mouth'

Long-term use of meth can take a heavy toll on a person, of course, but few examples of meth wear-and-tear are as graphic as the sort of severe tooth deterioration seen here. (Photo from TeethPictures.org.)

Usually the mainstream ‘authorities’ will tell you that this happens because of all the horrible, toxic chemicals used to make meth, like drain clog removers. The real story is a bit more complicated, so hold down your lunch and let’s talk tooth science!

Bacteria like to live on our teeth, since they get fed whenever we eat. In order to make sure they can (literally) stick around in the mouth the bacteria turn sugar into the sticky stuff we know as plaque. The metabolism of the bacteria creates a lot of acid as a waste product.

The outer layer of a tooth (the white part we see) is enamel. The enamel is mostly a crystal of calcium phosphate, which acid can slowly eat away. Our body’s main defense against this damage is saliva, which helps to wash away the acid being produced by bacteria before it can do too much damage. That’s why sugar-free gum can actually help prevent tooth decay: Chewing gum increases saliva production. Our main behavioral defense is brushing our teeth, since brushing can remove most of the bacteria and plaque that have built up during the day.

Heavy meth use is a sort of perfect storm for tooth destruction. It reduces saliva production (part of a water-conserving stress response that also contributes to hyponatremia deaths among ecstasy users), making it easier for acid levels to build up. People on a binge tend to have lousy nutrition (sugary drinks like soda seem to be particularly popular), and personal hygiene tends to be neglected (so the bacterial population isn’t being held in check by brushing.) Heavy meth users tend not to visit a dentist, either for regular checkups (or even when there clearly is deterioration.) As a result, the bacteria are free to run wild, creating a lot of acid to break down the user’s teeth.

‘Meth mouth’ can happen no matter how you get the drug into your system, although smoking probably makes things even worse, since the meth itself contains some acid. (The acid acts like tiny magnets, holding the meth molecules together into crystals. If you removed the acid, you would have methamphetamine freebase, which is an oily liquid; a bit hard to transport and sell.)

Stimulants like meth (and ecstasy, for that matter) also tend to cause bruxism (clenching and grinding your teeth.) This can wear down enamel by itself, can create grooves in your teeth that make a great hiding place for bacteria to grow in, and in severe cases can even crack the enamel (after all, it’s a crystal.)

If you’re going to use meth (or any other drug), I think the best advice is to be very careful about the frequency of use creeping up over time. Addiction doesn’t simply leap into existence over-night. Nobody gets addicted from one dose. Instead, you get hooked a little bit at a time, slowly and subtly enough that you usually don’t even notice it’s happening until it’s too late.

The only entirely safe drug use is not to use. If you do use, safer drug use means limiting dosages and the frequency of use. Pay attention to how often you use, how much you take, and whether you’re getting cravings to use. If your usage (or side effects) creep upwards over time, take a break for several months. If that seems like too much of a sacrifice, that’s all the more reason to be afraid of where things might be going.

Merck Pharmaceuticals digs the lost history of MDMA (Ecstasy) out of their archives (8/23/06)

It’s become conventional wisdom among a lot of people that MDMA was originally developed as an appetite suppressant. There was never any evidence to support such claims, but that hasn’t stopped them from popping up in even respectable research journals. Perhaps taking a new interest in what may become a commercially valuable drug, Merck, the company that first created MDMA in 1912, has gone through their own records to find out what exactly they did create the substance for.

Nobody knew MDMA was a psychoactive drug at first. Instead, they created what would eventually become ‘ecstasy’ as an insignificant intermediate chemical used to manufacture other, potentially useful medications to control bleeding.

In 1927, a Merck researcher rediscovered MDMA, noting that it had a structural similarity to adrenaline. Animal experiments were performed, but the details have been lost beyond some notes that MDMA was somewhat toxic and promoted muscle contraction, etc. His investigation was apparently brief, noting that the chemicals needed to produce MDMA were expensive and it’s potential use as a stimulant was intriguing but unproven.

In 1952 MDMA appeared again at Merck in the form of a brief note that flies exposed to the substance became unconscious, then died.

In 1959, an investigation into MDMA’s potential use as a stimulant was again undertaken, but the details have been lost. The first human tests may have occurred in 1959 or shortly thereafter. Thirteen years later, MDMA was discovered being sold as a drug in Chicago.

See: What is Molly? The history of MDMA.

Depressed, Anxious Children More Likely To Try 'Ecstasy' (1/1/06)

Reporting on the results of a study of 1580 Dutch children over a 14 year period, researchers have found that depression or anxiety problems during childhood doubled the likelihood that a child would eventually try ‘ecstasy’. This result is consistent with earlier findings that psychological problems in general increased the likelihood of ‘ecstasy’ use later in life.

This correlation between childhood emotional problems and drug use is not in of itself new, although detailed data of the connection between specific problems and ‘ecstasy’ use is. Given that emotionally troubled people are also at greater risk of drug addiction, childhood mental health intervention may prove to be an invaluable tool for combating drug abuse and addiction later in life.

Read the journal article.

Supreme Court Unanimously Upholds Use of Psychedelic Tea (Ayahuasca) (2/21/06)

In an 8-0 ruling led by the conservative new Chief Justice Roberts, the US Supreme Court has struck down government efforts to prevent the religious group O Centro Espirita Beneficiente Uniao do Vegetal (UDV) from importing and using ayahuasca (‘huasca’), a hallucinogenic tea containing N,N-dimethyltryptamine (DMT, a Schedule 1 drug.)

The use of ayahuasca for shamanic practices and healing rituals dates back thousands of years in South America. The UDV church was founded in Brazil, combining Christian teachings with the shamanic traditions of the rain forest’s native peoples. There are about 130 members in the US (although the church has a far larger presence in Brazil.)

The group came under fire when customs intercepted a shipment of the sacramental tea (apparently 14 previous shipments of the drug-laced liquid had gone unnoticed.) Faced with the loss of their central religious sacrament and threats of arrest, the Church sued the US government, claiming that the Religious Freedom Restoration Act (a law passed in 1993 primarily to protect the rights of peyote using Native American tribes) exempted them from the Controlled Substances Act (which outlaws DMT.) The government countered that there was a compelling interest (as required by the RFR Act) to stop the use of ayahuasca to 1. Protect the health of Church members; 2. Prevent diversion of the tea to the black market; and 3. To uphold international (UN) drug control treaties. The court ruled that the government had failed to make a convincing argument on any of these grounds, upholding the decision of a lower court that the Church had the right to practice their religion by using ayahuasca.

While certainly a triumph for the UDV, this ruling may also pave the way for other religious groups who use psychoactive drugs as part of their practices (such as the Rastafarians, who use marijuana, albeit in a less ritualized manner than the UDV uses ayahuasca.)

Read the Supreme Court Ruling